For Healthcare Professionals

Pacertool develops the proprietary PaCRTool-system with the aim to provide guidance for pacemaker implantations for heart failure patients.

Pacemakers are effectively restoring chronotropic competency, and optimizing AV-intervals and VV-intervals. However, pacing will inevitably change the intrinsic conduction patterns in the myocardium. The conduction system (His-Purkinje) secures equal and synchronous timing of myocardial activation. Any aberrancy in the intrinsic conduction system resulting from conduction block or from artificial stimulation may lead to dyssynchronous activation of the heart. While the mechanism of dyssynchronous activation leading to heart failure is not completely understood, it is likely caused by a chronic imbalance in regional myocardial load and energy supply in dyssynchronous hearts.

Restoration of a better balance between load and energy supply may occur with cardiac resynchronization therapy (CRT). CRT is either effective biventricular pacing or effective conduction system pacing. Biventricular pacing may lead to full recovery from heart failure in selected patients with left bundle branch block or pacemakers, and conduction system pacing is likely to contribute with similar benefits. There are currently no available markers of effective resynchronization therapy.

Pacertool aims to help facilitate CRT, with either traditional biventricular pacing or conduction system pacing, and to help understand when treatment is effective. Pacertool develops technology to quantify effective resynchronization so that the operator can understand when treatment is effectively applied in heart failure patients and then optimize therapy. The aim is to deliver personalized therapy and precision medicine to heart failure patients.